Marshak Science Building
The Marshak Science Building, for decades the only laboratory facility at the City College of New York, is getting a major face lift. At the same time, it’s losing pride of place on campus. The 13 -story concrete structure, designed by SOM in 1971, is currently undergoing a rehabilitation of its original concrete facade, and receiving a completely new glass curtain wall courtesy of Ahuja Partnership Architects and RSD Engineering.
- 3 ultracentrifuges and several high-speed centrifuge units, a cold room and dark room, a scintillation counter, bacterial shaking incubators, x-ray developer, a Gel Doc system, FPLC equipment, Nanodrop spectrophotometer, TECAN Fluorescent Plate reader, slide spinner, warm rooms, table top refrigerated centrifuges, sonicator, cell disruption equipment and 2-Real time PCR machines There are 3 autoclaves and a glassware washer in a separate room.
- Eukaryotic cell culture facility was established and equipped with two laminar flow hoods, centrifuges, refrigerators, freezers, a deionized water system and incubators for shared use.
- The Nuclear Magnetic Resonance Spectroscopy (NMR), also a shared research facility, consists of a 600-MHz NMR spectrometer for structural biology experiments and a 500-MHz spectrometer for organic chemistry research. A 300-MHz spectrometer is also part of the NMR core, and is primarily used in NMR instruction.
- Several groups employ our multi-user mass spectral facility, with GC-MS, EI, CI, DCI, and FAB capabilities, extensively. At present, it is operated mostly in the GC-MS, CI, and FAB modes. The FAB gun is particularly useful for the analysis of nonvolatile, high molecular weight samples. The usefulness of the instrument was extended with the purchase of electro-spray ionization capabilities. The instrument now permits the analysis of molecules as large as 100,000 kD, thus allowing the analysis of large peptides, glycosylation patterns, etc., important in biochemical and molecular biological studies. This facility is now completely maintained and operated by the College.
- Soon after beginning our program, we converted the animal room that housed classroom animals into an animal care facility for research animals. We hired a veterinarian and two animal technicians, bought supplies and animals, all with RCMI funds. In 2007, the College, again with its commitment to our program, institutionalized our facility and constructed an eight room, 5,000 square feet vivarium, which is attached to the science building through a short hallway on the ground level.
- Our new imaging core, built in 2008 by the science division, and grown out of the facility initially established by the RCMI program, added a new inverted Nikon fluorescence microscope with long term live cell imaging capacity and advanced counting and analysis software.
- The electron microscopy facility, located in the Marshak Science, has three electron microscopes available for research. There is a Zeiss EM 902, which is an 80 kV transmission electron microscope (TEM) with a point resolution of 0.5 nm, a Zeiss DSM 940 thermionic scanning electron microscope (SEM), which has a maximum resolution of 5 nm at 30 kV, and a Zeiss Supra 55 VP field emission SEM that has a maximum resolution of 1 nm. Usage: The SEM and the TEM are available to all investigators in the Science building.
Advanced Science Research Center
A new science research center on the City University of New York’s new South Campus at City College in Harlem pulls the existing campus grid lines across 135th Street and twists them into undulating curves. Designed by Kohn Pedersen Fox (KPF), the two glass 200,000-square-foot research buildings are set on an elevated rock outcropping along St. Nicholas Park, graciously accommodating the jagged environs.
- With the construction of the 2 new science buildings ASRC and CDI on our south campus a new state of the art animal facility was constructed in the basement with access from both buildings. This facility is managed by CUNY and a separate vet and IACUC but is used by all faculty that moved to the new facilities including members of Areas I, III and IV.