Dr. David Jeruzalmi

The faithful transmission of genetic information is an important biological imperative. To carry out this function, organisms have evolved processes to replicate their genomes and defend them from attack. We study two important mechanisms associated with these processes, DNA replication and Repair. The central challenge in understanding these processes stems from the large size of the involved multi-protein•DNA complexes; these entities also populate many conformational states. Together, these complications place limits on the insights that can be revealed by solution methods alone. As such, structural information is a prerequisite for analyses of the underlying mechanisms. To this end, my group applies X-ray crystallography, supplemented with electron microscopy, to understand these long-standing problems in DNA biology. We also use biochemical studies to inform these approaches and follow up on the resulting insights.





David Jeruzalmi
Department of Chemistry
The City College of New York
The Graduate Center of the City University of New York
Marshak Science Building
160 Convent Avenue
New York, NY 10031
t. 212.650.6062 – MR 1219