Dr. Kevin Ryan
Dr. Ryan is an biochemist/organic chemist/molecular biologist whose research falls in three areas: (1) olfactory molecular recognition, (2) mammalian pre-mRNA processing, and (3) small RNA delivery vectors.
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(1) The nose is a chemical detector. We study the molecular recognition of small molecules by the odorant receptors expressed in olfactory sensory neurons found in the nasal epithelium. The various sub projects are on a day to day basis pharmacological and medicinal chemistry in nature, but our goals are not to develop a new drug but to understand the biochemistry of olfaction. This project is collaboration with the Stuart Firestein lab at Columbia University.
(2) Another project focuses on the regulation of the pre-mRNA 3’ cleavage step that precedes the polyadenylation of nearly all human mRNAs. We have found that phosphorylation among the 3’ cleavage factors can control the in vitro reconstituted reaction, and are seeking to identify the factors involved, as well as the kinase-phosphatase pair that is responsible for phospho-transfer.
(3) We are also developing unorthodox vectors for producing small RNAs within human cells.
Kevin Ryan, Ph. D.
Department of Chemistry and Biochemistry
City College of New York
160 Convent Avenue
New York, NY 10031
t. 212.650.8302 Lab