Dr. Zimei Bu
Dr. Zimei Bu is a member of Area Group I and the Immunology Subgroup of the RCMI. The research interest of her group includes the development of antiviral drugs against the HIV-1 virus, antifungal drugs effective against the opportunistic pathogens (OIs), and the development of nanotechnology-based multifunctional materials for theranostic applications.
We study the structure and dynamics of cell signaling proteins. We are particularly interested in signaling proteins that control cell-cell adhesion, and the assembly and intracellular trafficking of membrane receptors and ion channels. These proteins function as molecular machines and switches, which can fail to work properly for various reasons, causing diseases such as cancer and cystic fibrosis. We employ a variety of biochemical and cell biological experiments, as well as biophysical and structural biology techniques, including small angle X-ray and neutron scattering, to study the interactions of these proteins
We have also pioneered methods of utilizing quasielastic neutron scattering, particularly neutron spin echo spectroscopy, to study protein dynamics and protein domain motion. We have developed a theoretical framework using statistical mechanics to interpret the NSE data. These methods allow us to see, for the first time, the structure and dynamics of significant protein interactions on nanoscales. NSE fill an important information gap in our ability to study protein motion on sub-microsecond time scales and on nanomenter length scales.
Dr. Zimei Bu
Department of Chemistry, Room MR-1305
City College of New York
160 Convent Avenue
New York, NY 10031
Phone: 212.650.8169 (office)
Phone: 212.650.6071 (lab)